diff --git a/app/javascript/mastodon/features/ui/components/block_modal.jsx b/app/javascript/mastodon/features/ui/components/block_modal.jsx
index fc9233a9c..d6fc6c415 100644
--- a/app/javascript/mastodon/features/ui/components/block_modal.jsx
+++ b/app/javascript/mastodon/features/ui/components/block_modal.jsx
@@ -99,7 +99,7 @@ export const BlockModal = ({ accountId, acct }) => {
             <FormattedMessage id='confirmation_modal.cancel' defaultMessage='Cancel' />
           </button>
 
-          <Button onClick={handleClick}>
+          <Button onClick={handleClick} autoFocus>
             <FormattedMessage id='confirmations.block.confirm' defaultMessage='Block' />
           </Button>
         </div>
diff --git a/app/javascript/mastodon/features/ui/components/confirmation_modals/confirmation_modal.tsx b/app/javascript/mastodon/features/ui/components/confirmation_modals/confirmation_modal.tsx
index c3a0c0aa7..ab567c697 100644
--- a/app/javascript/mastodon/features/ui/components/confirmation_modals/confirmation_modal.tsx
+++ b/app/javascript/mastodon/features/ui/components/confirmation_modals/confirmation_modal.tsx
@@ -71,7 +71,10 @@ export const ConfirmationModal: React.FC<
             />
           </button>
 
-          <Button onClick={handleClick}>{confirm}</Button>
+          {/* eslint-disable-next-line jsx-a11y/no-autofocus -- we are in a modal and thus autofocusing is justified */}
+          <Button onClick={handleClick} autoFocus>
+            {confirm}
+          </Button>
         </div>
       </div>
     </div>
diff --git a/app/javascript/mastodon/features/ui/components/domain_block_modal.jsx b/app/javascript/mastodon/features/ui/components/domain_block_modal.jsx
index e69db6348..78d5cbb13 100644
--- a/app/javascript/mastodon/features/ui/components/domain_block_modal.jsx
+++ b/app/javascript/mastodon/features/ui/components/domain_block_modal.jsx
@@ -88,7 +88,7 @@ export const DomainBlockModal = ({ domain, accountId, acct }) => {
             <FormattedMessage id='confirmation_modal.cancel' defaultMessage='Cancel' />
           </button>
 
-          <Button onClick={handleClick}>
+          <Button onClick={handleClick} autoFocus>
             <FormattedMessage id='domain_block_modal.block' defaultMessage='Block server' />
           </Button>
         </div>
diff --git a/app/javascript/mastodon/features/ui/components/mute_modal.jsx b/app/javascript/mastodon/features/ui/components/mute_modal.jsx
index df466cfac..70d95b593 100644
--- a/app/javascript/mastodon/features/ui/components/mute_modal.jsx
+++ b/app/javascript/mastodon/features/ui/components/mute_modal.jsx
@@ -137,7 +137,7 @@ export const MuteModal = ({ accountId, acct }) => {
             <FormattedMessage id='confirmation_modal.cancel' defaultMessage='Cancel' />
           </button>
 
-          <Button onClick={handleClick}>
+          <Button onClick={handleClick} autoFocus>
             <FormattedMessage id='confirmations.mute.confirm' defaultMessage='Mute' />
           </Button>
         </div>